The Mongolian script used by the Mongolian nationality in the northern border of China embodies pluralistic characteristics visually; letters of the Mongolian script originate from the Phoenician alphabet like most other alphabetic writing systems, but it runs in vertical columns of oriental style. Therefore, it is a typical example of the renaissance of regional civilization energized by integrating regional characteristics into the worldwide universal civilization. Based on the development of the times and the evolution of media technology, this presentation reveals the design characteristics of the Mongolian letters and fonts, the process of standardization as well as the constant part in font design and the superficial phenomena thereof. On this basis, this presentation discusses the multiple paths connected to different cultures in the history of font design of the Mongolian script, the interactions and mutual influences in the active process of cooperation between people from different regions, and an active interactive behavior between openness and fluidity based on cultural consciousness, all of which jointly built the magnificent history of font design of the Mongolian script. This further constructed the natural, historical, and national characteristics of cultural exchange in font design.